The NovaDose System: Daily Microdosing for Precision Research

The NovaDose system represents ORYN's next-generation peptide delivery platform, designed specifically for daily microdosing protocols. Unlike standard peptide pens that deliver fixed or semi-fixed doses, the NovaDose features a fully adjustable dosing mechanism with interchangeable cartridges.

Launched with NAD+ as its first compound, the NovaDose NAD+ (€299) addresses a critical gap in research: the need for precise, repeatable, daily-dose NAD+ delivery without the complexity of IV infusions or the imprecision of manual syringe preparation.

The NovaDose concept was developed in response to emerging research suggesting that daily low-dose NAD+ administration may produce different (and potentially more sustained) metabolic effects compared to intermittent high-dose protocols. This microdosing approach aligns with pharmacological principles of maintaining steady-state plasma concentrations.

Hardware: - Precision dial-a-dose mechanism with audible click confirmation - Adjustable dose range for titration protocols - Ergonomic pen-style design for daily use comfort - Compatible with standard pen needles (31G or 32G) - Medical-grade materials throughout

NAD+ Cartridge: - Pre-mixed, sterile NAD+ solution - >99% purity (HPLC verified) - 0.22μm sterile filtered - Sealed cartridge system (no external exposure) - Refrigerated storage at 2-8°C - 24-month shelf life

Quality Assurance: - GMP-certified manufacturing (South Korea) - Batch-specific Certificate of Analysis - Gamma ray sterilisation - Individual unit inspection and calibration

The cartridge-based design means the NovaDose pen body is reusable — only the NAD+ cartridge needs replacement when depleted, reducing waste and long-term cost for extended research programmes.

Traditional NAD+ administration in research has followed two main approaches:

High-dose intermittent (e.g., IV infusions): - 250-500 mg NAD+ delivered over 2-4 hours - Produces high peak levels followed by rapid clearance - Requires clinical setting and professional administration - Peaks-and-troughs pharmacokinetic profile

Standard daily subcutaneous (e.g., NAD+ Pen): - Fixed daily dose via pen injection - More sustained levels than IV but still once-daily dosing - Convenient and self-administrable - Good steady-state approximation

Precision microdosing (NovaDose approach): - Adjustable daily doses allow titration to optimal response - Maintains consistent NAD+ levels with minimal peak-trough variation - Enables dose-response research across a continuous range - Daily adjustment based on protocol requirements or biomarker feedback

The microdosing rationale draws on research showing that NAD+-dependent enzymes (sirtuins, PARPs) respond to sustained NAD+ availability rather than transient spikes. Maintaining steady-state NAD+ levels may produce more consistent sirtuin activation and more predictable metabolic outcomes.

ORYN offers two NAD+ delivery systems to match different research needs:

NAD+ Pen (€189): - Fixed-dose daily delivery - Simple click-and-inject operation - 30-day supply per pen - Ideal for standardised protocols with fixed dosing - Best for: researchers running established protocols where dose consistency is the priority

NovaDose NAD+ (€299): - Adjustable-dose daily delivery - Precision dial mechanism for titration - Cartridge-based system with reusable pen body - Ideal for dose-finding studies, titration protocols, and personalised research - Best for: researchers exploring dose-response relationships or needing flexible dosing

When to choose NovaDose: - Dose-response characterisation studies - Protocols requiring dose adjustment based on biomarker data - Multi-phase research with different dose levels - Precision research where small dose increments matter - Long-term studies where cartridge replacement is more economical

When the standard pen is sufficient: - Fixed-dose replication studies - Cost-sensitive protocols - Short-duration research (single 30-day cycle) - Comparative studies requiring identical dosing across subjects

Both products are available in the NAD+ Complete Stack (12% off) during the Peak Performance campaign.

The adjustable dosing of NovaDose enables several research designs that are difficult with fixed-dose systems:

Dose-Escalation Protocol: - Week 1-2: Low dose (establish baseline tolerance and biomarkers) - Week 3-4: Medium dose (moderate NAD+ repletion) - Week 5-8: Target dose (full protocol dose) - Week 9-12: Maintenance or further escalation based on biomarker response

Dose-Response Characterisation: - Systematic dose increases with biomarker measurements at each level - NAD+ blood levels, PBMC NAD+ content, sirtuin activity markers - Identify minimum effective dose for specific endpoints

Biomarker-Guided Titration: - Baseline NAD+ measurement (blood or tissue) - Initiate at a conservative dose - Adjust dose based on periodic NAD+ level monitoring - Target a specific NAD+ restoration percentage (e.g., restore to youthful range)

Chronobiology Protocol: - Vary dosing time and amount to investigate circadian NAD+ requirements - Morning vs evening administration comparison - Align with circadian sirtuin activity patterns (SIRT1 is clock-regulated)

The NovaDose system's precision makes it uniquely suited for these protocol designs, where even small dose variations can meaningfully impact research outcomes.

Ordering and Setup: 1. Order NovaDose NAD+ from ORYN (€299, includes pen device + first NAD+ cartridge) 2. Store cartridge at 2-8°C upon receipt 3. Attach a disposable pen needle (31G or 32G recommended) 4. Dial to the desired dose using the precision mechanism 5. Administer subcutaneously (abdomen or thigh) 6. Dispose of needle safely after each use

Storage and Handling: - Cartridge: Always refrigerate at 2-8°C - Pen body: Store at room temperature when not in use - Attached cartridge: Keep refrigerated between uses - Do not freeze - Protect from direct sunlight

Cartridge Replacement: - When the current cartridge is depleted, simply swap in a new one - The pen body does not need replacement - Replacement cartridges are available separately

Documentation for Research: - Each cartridge includes a batch-specific Certificate of Analysis - HPLC purity data, mass spectrometry confirmation - Sterility testing results - Stability data

For researchers interested in the NovaDose system, the Peak Performance campaign (May 15 – June 30) offers it as part of the NAD+ Complete Stack alongside the standard NAD+ Pen. Visit /peak-performance for bundle pricing and details.

All ORYN products are sold strictly for research purposes only.