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PARCOURIR LES PRODUITSA ribonucleoprotein enzyme that extends telomere length by adding TTAGGG repeats to chromosome ends, counteracting the replicative shortening that drives cellular ageing.
Telomerase is a specialised reverse transcriptase enzyme composed of a catalytic protein subunit (hTERT) and an RNA template component (hTR/TERC) that synthesises telomeric DNA repeats (TTAGGG in humans) at chromosome ends. In most adult somatic cells, telomerase expression is repressed, leading to progressive telomere shortening with each cell division until critically short telomeres trigger replicative senescence or apoptosis. Telomerase is constitutively active in stem cells, germ cells, and most cancer cells, enabling their extended proliferative capacity. Research into telomerase activation as an anti-ageing strategy has identified several compounds that upregulate hTERT expression. The synthetic peptide Epithalon (Ala-Glu-Asp-Gly), modelled on the naturally occurring pineal peptide epithalamin, has been studied for its ability to activate telomerase in human somatic cells, potentially extending their replicative lifespan. NAD+ and sirtuin pathways also intersect with telomere biology, as SIRT1 and SIRT6 are involved in telomere maintenance and DNA damage response at dysfunctional telomeres.
BIOLOGY
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Repetitive DNA sequences (TTAGGG) at chromosome ends that protect genetic information during cell division, progressively shortening with age.
The irreversible state of cell cycle arrest in which cells remain metabolically active but stop dividing, contributing to tissue aging and chronic inflammation.
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the naturally occurring pineal gland peptide epithalamin, studied for its telomerase-activating and anti-ageing properties.
Nicotinamide Adenine Dinucleotide, an essential coenzyme in every living cell that drives energy metabolism, DNA repair, and sirtuin-mediated longevity pathways.
The active growth phase of the hair follicle cycle, lasting 2-7 years, during which the hair shaft elongates from a fully formed hair bulb.
A cluster of specialised mesenchymal cells at the base of the hair follicle that controls hair growth, cycling, and follicle regeneration.
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