COMPLETE RESEARCH GUIDEPEPTIDE PEN
Ipamorelin
Selective GH Secretagogue
>99%6 mgFROM EUR 109
QUICK ANSWER
Ipamorelin (selective gh secretagogue) is a >99% purity research compound. A selective growth hormone secretagogue investigated for its ability to stimulate pituitary GH release via the ghrelin receptor. Research suggests Ipamorelin may offer selective GH modulation without broader hormonal disruption. ORYN delivers Ipamorelin in a precision-dosed reusable pen starting from EUR 109. All products are for research purposes only.
Science & Research
FULL ENCYCLOPEDIA ENTRY →MOLECULAR PROFILE
FORMULA
C38H49N9O5
WEIGHT
711.85 Da
CLASSIFICATION
Growth Hormone Secretagogue / Ghrelin Receptor Agonist
STUDIES CITED
4 key studies
Mechanism of Action
Ipamorelin is a selective pentapeptide that acts as an agonist at the growth hormone secretagogue receptor (GHS-R1a), also known as the ghrelin receptor, located on somatotroph cells of the anterior pituitary. By mimicking the endogenous hunger hormone ghrelin at this receptor, it triggers a targeted pulse of growth hormone release.
READ FULL MECHANISM →Key Published Studies
1998
Ipamorelin, the first selective growth hormone secretagogue
Demonstrated that Ipamorelin releases GH in a dose-dependent manner without affecting cortisol, prolactin, ACTH, FSH, LH, or TSH — the first GHS-R agonist to show this selectivity.
2001
Effects of ipamorelin on bone mineral content in rats
Showed significant increases in bone mineral content and bone strength in ovariectomised rats, suggesting applications in osteoporosis research.
2008
Ipamorelin for post-operative gastric ileus: Phase II trial
Demonstrated accelerated recovery of gastrointestinal motility following abdominal surgery, the first clinical trial of a GHS-R agonist for gut motility.
2011
Synergistic GH release from combined GHRH and GHS-R agonist administration
Confirmed that combining Ipamorelin with GHRH analogues produces synergistic GH release exceeding the sum of individual effects.
Research History
Ipamorelin was first described in 1998 by researchers at Novo Nordisk as part of a programme to develop selective GH secretagogues with fewer side effects than existing compounds. The initial characterisation demonstrated its remarkable selectivity — releasing GH without affecting cortisol, prolactin, FSH, LH, or TSH levels.
FULL RESEARCH HISTORY →ORYN Ipamorelin Product
PEPTIDE PEN
Ipamorelin — Selective GH Secretagogue
A selective growth hormone secretagogue investigated for its ability to stimulate pituitary GH release via the ghrelin receptor. Research suggests Ipamorelin may offer selective GH modulation without broader hormonal disruption. ORYN Ipamorelin delivers 6mg/3ml in a reusable pen system for 30 days of targeted dosing.
PURITY
>99%
FILL VOLUME
3 mL
DOSAGE
6 mg
FORMULATION
Pharma Grade
DOSING PERIOD
30 Days
STERILIZATION
0.22um Filter + Gamma Ray
EUR 109VIEW PRODUCT DETAILS
Articles & Guides
ALL ARTICLES →GUIDES
Peptide Pen vs Vial: Which Is Better for Research?
A detailed comparison of peptide pen systems versus traditional vials for research applications. Why pre-mixed pens are becoming the new standard.
6 min read
GUIDES
How to Use a Peptide Pen: Step-by-Step Guide
Step-by-step instructions for using ORYN peptide pen systems. From unboxing to administration, everything you need to know.
5 min read
PEPTIDE RESEARCH
Ipamorelin vs CJC-1295: Growth Hormone Peptide Comparison
A comprehensive comparison of ipamorelin and CJC-1295 — two growth hormone peptides with distinct mechanisms and powerful synergy when used together.
9 min read
RESEARCH GUIDES
Peptides for Athletes & Sports Recovery UK: Research Guide 2026
An in-depth look at peptide research relevant to athletic performance, sports recovery, and exercise science in the UK.
11 min read
RESEARCH GUIDES
Peptide Stacking Guide UK: Best Combinations for Research 2026
Evidence-based guide to combining peptides for enhanced research outcomes. Popular stacks, synergistic mechanisms, timing considerations, and ORYN product pairings.
11 min read
BUYING GUIDES
Best Value Peptides UK 2026: Price Comparison Guide
A comprehensive price comparison of research peptides across UK suppliers in 2026. Why cheapest isn't always best value, and how to calculate true cost per dose.
9 min read
Head-to-Head Comparisons
ALL COMPARISONS →COMPARISON
CJC-1295 vs Ipamorelin: Growth Hormone Peptides Compared
CJC-1295VSIpamorelin
CJC-1295 and Ipamorelin work through different GH pathways and are most commonly studied together for synergistic effects. CJC-1295 extends GH release duration, while Ipamorelin triggers clean GH pulses. The combination is one of the most popular GH research stacks.
COMPARISON
TB-500 vs Ipamorelin: Recovery Peptide vs Growth Hormone Secretagogue
TB-500VSIpamorelin
TB-500 and Ipamorelin serve fundamentally different purposes. TB-500 is a direct tissue repair peptide that promotes cell migration and wound healing. Ipamorelin is a selective growth hormone secretagogue that triggers natural GH pulses. Researchers focused on acute recovery choose TB-500; those studying GH-mediated effects — body composition, sleep, anti-ageing — choose Ipamorelin. They can also be combined for comprehensive recovery-plus-growth protocols.
COMPARISON
Ipamorelin vs Tirzepatide: Growth Hormone vs Metabolic Peptide
IpamorelinVSTirzepatide
Ipamorelin and Tirzepatide are entirely different classes of peptide. Ipamorelin is a selective growth hormone secretagogue — ideal for research into GH-mediated effects like body composition, sleep, and recovery. Tirzepatide is a dual GIP/GLP-1 receptor agonist — the leading compound for metabolic and weight management research. The choice depends entirely on your research focus: growth hormone biology or metabolic science.
COMPARISON
Ipamorelin vs CJC-1295: Two GH Peptides, Different Mechanisms
IpamorelinVSCJC-1295
Ipamorelin and CJC-1295 both stimulate growth hormone release but through entirely different receptor pathways. Ipamorelin triggers clean, selective GH pulses via the ghrelin receptor. CJC-1295 extends GH release duration via the GHRH pathway. Individually, each is effective. Together, they produce synergistic GH elevation that exceeds either compound alone — which is why the CJC-1295 + Ipamorelin stack is the most popular GH research protocol worldwide.
COMPARISON
Ipamorelin vs CJC-1295: Solo Use vs Stacking for GH Research
IpamorelinVSCJC-1295
Ipamorelin solo is the cleanest, safest GH secretagogue with minimal hormonal side effects -- ideal for beginners or GH-isolated research. CJC-1295 solo provides sustained GH elevation for more aggressive protocols. However, the combination of both is the gold standard, producing synergistic GH release through dual-pathway activation that exceeds either peptide alone.
COMPARISON
CJC-1295 vs Ipamorelin vs Both: Complete GH Peptide Decision Guide
CJC-1295VSIpamorelin
Each option serves a distinct purpose. CJC-1295 solo provides sustained GH elevation for body composition and IGF-1-focused research. Ipamorelin solo provides clean, pulsatile GH release with the fewest side effects -- ideal for GH-isolated studies. The combination is the gold standard, producing synergistic GH output through dual-pathway activation. For most researchers, the stack is worth the additional investment.
Research Protocols
ALL PROTOCOLS →Frequently Asked Questions
FULL FAQ →What is Ipamorelin and why is it considered selective?
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Ipamorelin is a synthetic pentapeptide that stimulates growth hormone release by activating the ghrelin receptor (GHS-R1a). Unlike other GH secretagogues, it does not significantly affect cortisol, prolactin, ACTH, or other hormones — making it the most selective GH-releasing peptide discovered, with the cleanest side-effect profile.
How does Ipamorelin differ from other GH peptides?
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Ipamorelin's selectivity sets it apart. While GHRP-6 can increase cortisol by up to 50% and stimulate intense hunger, Ipamorelin produces a focused GH pulse with negligible effects on other hormones. It also has a dose-dependent, saturable response — meaning it cannot overshoot to supraphysiological GH levels.
What research has been done on Ipamorelin?
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Since its discovery in 1998 by Novo Nordisk, Ipamorelin has been studied for GH selectivity, bone density improvement, gut motility recovery (Phase II clinical trial for post-operative ileus), sleep quality, and synergistic GH release when combined with GHRH analogues like CJC-1295.
How does ORYN deliver Ipamorelin?
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ORYN Ipamorelin is formulated at 6mg in a 3mL precision pen system with >99% purity. The pre-mixed pen provides consistent dosing over 30 days. It is often used in research protocols alongside ORYN CJC-1295 for synergistic GH release studies.
What is Ipamorelin?
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Ipamorelin is a synthetic pentapeptide (5 amino acids) that acts as a selective growth hormone secretagogue. It stimulates the pituitary gland to release growth hormone by activating the ghrelin/GHS receptor. ORYN Ipamorelin is formulated at >99% purity with 6 mg in a precision pen system.
How does Ipamorelin work?
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Ipamorelin binds to the growth hormone secretagogue receptor (GHS-R) on pituitary cells, triggering a calcium-dependent signalling cascade that promotes GH release. Unlike other GH secretagogues, Ipamorelin is highly selective — it does not significantly stimulate ACTH, cortisol, or prolactin release, which is a key advantage noted in published research.
What is Ipamorelin used for in research?
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Ipamorelin is researched for GH stimulation, body composition studies, bone density, sleep architecture, post-operative recovery models, and age-related growth hormone decline. Its selectivity makes it particularly valuable in studies requiring isolated GH elevation without broader hormonal disruption.
How is ORYN Ipamorelin administered?
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ORYN Ipamorelin is delivered through a pre-mixed pen containing 6 mg in 3 mL of solution. The pen is designed for subcutaneous injection with click-based dosing precision. Administration is typically timed for the evening or pre-sleep to complement natural GH secretion patterns.
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RESEARCH PURPOSES ONLY. All content on this page is intended for informational and educational purposes for qualified researchers. ORYN products are not approved as medicines and are not intended for human therapeutic use. Do not use ORYN products for self-administration. Consult relevant regulations in your jurisdiction.