GHK-Cu: The Structural Repair Peptide
GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring tripeptide with a high affinity for copper ions. Research spanning over 40 years has established its role in tissue remodelling:
Collagen & Elastin: GHK-Cu activates genes responsible for collagen types I and III synthesis, as well as elastin production. This directly improves skin structural integrity.
Glycosaminoglycans: Increases production of GAGs including hyaluronic acid, improving skin hydration and plumpness.
Growth Factors: Stimulates release of TGF-β and other growth factors involved in tissue repair.
Gene Expression: Studies show GHK-Cu can modulate expression of over 4,000 genes, with a pattern that shifts gene activity from an aged to a more youthful profile.
Glutathione: The Master Antioxidant
Glutathione is a tripeptide (L-glutamate, L-cysteine, L-glycine) present in every cell. It serves as the body's primary defence against oxidative stress:
Antioxidant Defence: Directly neutralises free radicals and reactive oxygen species. Regenerates other antioxidants (vitamins C and E).
Detoxification: Conjugates toxins in the liver via glutathione S-transferase enzymes, facilitating their elimination.
Melanin Regulation: Inhibits tyrosinase activity and shifts melanin production from eumelanin (dark) to pheomelanin (light), producing documented skin brightening effects.
Bioavailability Advantage: ORYN's pen-delivered Glutathione bypasses digestive degradation entirely, delivering 6g of active compound with near-complete bioavailability — far superior to oral supplements.
Combining GHK-Cu and Glutathione
These two compounds target complementary pathways and are commonly studied together:
GHK-Cu rebuilds: Stimulates new collagen, elastin, and GAG production — rebuilding the skin's structural framework.
Glutathione protects: Neutralises the oxidative damage that degrades existing collagen and causes premature aging.
Together, they address both the cause (oxidative stress) and the effect (structural protein loss) of skin aging. This makes the GHK-Cu + Glutathione combination one of the most comprehensive approaches to skin and anti-aging research.
ORYN Combined Cost: €139 + €99 = €238 for two 30-day pens covering both structural repair and antioxidant defence.
