Mitochondrial Cleansing and Oxidative Stress Reduction
8-12 weeks
Daily subcutaneous injection
2 peptides
The detox protocol focuses on two of the body's most fundamental endogenous defence systems: NAD+ (nicotinamide adenine dinucleotide) and glutathione. Both decline significantly with age, environmental toxin exposure, and metabolic dysfunction. This protocol is designed for researchers investigating cellular detoxification pathways, mitochondrial quality control, and oxidative stress resolution. NAD+ supports the SIRT1/PARP DNA repair axis and drives mitochondrial biogenesis, while glutathione serves as the master antioxidant for neutralising reactive oxygen species and conjugating xenobiotics for hepatic excretion.
NAD+ drives the activity of SIRT3 (a mitochondrial deacetylase), which activates superoxide dismutase 2 (SOD2) — the primary mitochondrial antioxidant enzyme. It also fuels PARP enzymes for DNA strand break repair following oxidative damage. Glutathione (GSH) directly neutralises hydrogen peroxide, lipid peroxides, and electrophilic xenobiotics via glutathione-S-transferase (GST) conjugation. GSH depletion is a hallmark of toxic liver injury models and heavy metal toxicity. Together, NAD+ and glutathione restore redox balance, support mitophagy (clearance of damaged mitochondria), and enhance Phase II hepatic detox pathways.
Most antioxidant protocols address exogenous antioxidants (vitamin C, E, etc.). This protocol targets the regeneration of the body's two most powerful endogenous antioxidant systems — NAD+ and glutathione — which are rate-limiting for overall redox defence.
NAD+ is required to regenerate NADPH, which in turn regenerates oxidised glutathione (GSSG) back to active GSH via glutathione reductase. Low NAD+ impairs glutathione recycling, creating a cascade effect on antioxidant capacity.
Glutathione depletion is a central mechanism in alcohol-induced hepatotoxicity and acetaminophen toxicity models. Restoring GSH is a primary research target in these models.
Key biomarkers include: serum glutathione (GSH/GSSG ratio), NAD+/NADH ratio (in cells), liver enzymes (ALT, AST), 8-hydroxydeoxyguanosine (8-OHdG) for oxidative DNA damage, and F2-isoprostanes for lipid peroxidation.
Detox and restoration research cycles typically run 4–12 weeks, with biomarker assessment at baseline, mid-point, and completion. Longer cycles are used in chronic toxin exposure models.
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ENCYCLOPEDIAEndogenous Antioxidant Tripeptide. Molecular weight: 307.32 Da. Explore mechanism of action, key studies, and research applications.
BUNDLETriple-compound protocol for cellular aging research
PROTOCOLResearch protocol for Glutathione peptide pen targeting immune function, oxidative stress reduction, and cellular detoxification. Explore antioxidant defense mechanisms and immunology research.
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All ORYN peptide pens are pre-mixed, >99% purity, GMP manufactured with next-day UK delivery.
FOR RESEARCH PURPOSES ONLY. NOT INTENDED FOR SELF-ADMINISTRATION.
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